中药蛇床子水溶性提取物中化学成分的抗诱变性研究

doi:10.3969/j.issn.1004-616x.1999.02.002

癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (2): 65-071.doi: 10.3969/j.issn.1004-616x.1999.02.002

中药蛇床子水溶性提取物中化学成分的抗诱变性研究

殷学军1 　向仁德2 　刘德祥1 　张新勇2 　许永华1 　韩　英2 　王　瑞1 　王河川1

1 兰州军区乌鲁本齐总医院　830000 　2 南京药物研究所　210009

收稿日期:1998-07-20 修回日期:1998-10-28 出版日期:1999-03-30 发布日期:1999-03-30

A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE

Yin Xuejun1 , Xiang Rende2 , Liu Dexiang1 , Zhang Xinyong2 , Xu Yonghua1 , Han Ying2 , Wang Rui1 , Wang Hechuan1

1 Instit ute of Clinical Medicine , Urumqi General Hospital of L anz hou Com mand , PL A , Urumqi 　830000 , 2Nanjing Instit ute of Materia Medica , Nanjing 　210009

Received:1998-07-20 Revised:1998-10-28 Online:1999-03-30 Published:1999-03-30

摘要/Abstract

摘要： 本文采用Ames、体内试验小鼠骨髓细胞染色体畸变和骨髓多染红细胞微核试验,对蛇床子水溶性提取物中9 种化学成分(蛇床子素、佛手柑内酯、异虎耳草素、欧芹属素乙、花椒毒酚、花椒毒素、甲基嘧啶、尿嘧啶和1 种待定化合物) 进行了抗诱变性研究。结果表明,蛇床子素、佛手柑内酯、异虎耳草素、欧芹属素乙、花椒毒酚和花椒毒素在黄曲霉菌素B1 诱变性的抑制作用中具有较高活性。蛇床子素、佛手柑内酯、异虎耳草素和欧芹属素乙在环磷酰胺诱发的染色体畸变和多染红细胞微核的抑制作用中也显示出较高活性。另外的3 种成分(甲基嘧啶、尿嘧啶和1 种待定化合物) 则无抗诱变性效应。

关键词: 蛇床子, 化学成分, 抗诱变性

Abstract: The antimutagenicity of 9 kinds of chemical compounds (osthol , Bergaten , Isopimpinellin , Imperatorin , Xanthotoxol , Xnthotoxin , Thymine , Uracil and unknown one that need authenticating) was studied with the Ames test and the micronucleus and chromosomal aberretion assays in mice in vivo. These compounds were isolated f rom the water ext ract of Cnidium monnieri (L. ) Cuss in Chinese t raditional medicine. The results showed that osthol. , bergapten , isopimpinellin , imperatorin , xanthotoxol and xanthotoxin had inhibited activity of mutagenicity of aflatoxin B1 . And osthol , bergapten , isopimpinellin , imperatorin also had high activity in inhibiting the chromosomal aberrations and micronuclei that induced by cyclophosphamid in vivo. The other three compounds ( Thymine , Uracil and unknown one that need authenticating) showed no antimutagenicity.

Key words: Cnidium monnieri (L. ) Cuss, chemical compound, antimutagenicity

殷学军　向仁德　刘德祥　张新勇　许永华　韩　英　王　瑞　王河川. 中药蛇床子水溶性提取物中化学成分的抗诱变性研究[J]. 癌变·畸变·突变, 1999, 11(2): 65-071.

Yin Xuejun , Xiang Rende , Liu Dexiang , Zhang Xinyong , Xu Yonghua , Han Ying , Wang Rui , Wang Hechuan. A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(2): 65-071.

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中药蛇床子水溶性提取物中化学成分的抗诱变性研究

A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNI ERI ( L) CUSS USED IN CHINESE TRADITIONAL MEDICINE

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